The evolution of comparative genomics

Comparative genomics of human stem cell factor (SCF)

Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...

UNIVERSITY of CALIFORNIA SANTA CRUZ COMPARATIVE MAMMALIAN GENOMICS: MODELS OF EVOLUTION AND DETECTION OF FUNCTIONAL ELEMENTS

Comparative Mammalian Genomics: Models of Evolution and Detection of Functional Elements

Comparative Genomics II: From Genomes to Evolution

Comparative Genomics II: From Genomes to Evolution

This is the second lecture in a series of two lectures on the work being done in Prof. Kellis’s lab on comparative genomics. Comparing genomes of related species at different evolutionary distances can teach us both about the genetic code and about evolution. In this lecture we discussed two examples of what we can learn about evolution using comparative genomics. The topics of this lecture are...

Linking Fold, Function and Phylogeny: A Comparative Genomics View on Protein (Domain) Evolution

Domains are the building blocks of all globular proteins and present one of the most useful levels at which protein function can be understood. Through recombination and duplication of a limited set of domains, proteomes evolved and the collection of protein superfamilies in an organism formed. As such, the presence of a shared domain can be regarded as an indicator of similar function and evol...

Comparative genomics - A perspective

The rapidly emerging field of comparative genomics has yielded dramatic results. Comparative genome analysis has become feasible with the availability of a number of completely sequenced genomes. Comparison of complete genomes between organisms allow for global views on genome evolution and the availability of many completely sequenced genomes increases the predictive power in deciphering the h...